THCV; characteristics, properties and effects
In research on the cannabis plant, minor cannabinoids such as THCV (tetrahydrocannabivarin) have made significant progress in recent years. THCV stands out from other cannabinoids due to its potential benefits in combating obesity. In addition, despite its structural similarity to THC, THCV is not psychoactive and is even thought to mitigate the psychoactive effects of THC.
In this article, we will look at what THCV is and its unique characteristics, properties and effects.
What is THCV?
THCV, or tetrahydrocannabivarin, is a non-psychoactive cannabinoid that occurs naturally in the cannabis plant. It is found in full-spectrum CBD oils as well as CBD flowers. This cannabinoid has unique properties that distinguish it from THC and CBD.
Similar to other cannabinoids, THCV is produced in the trichomes of the cannabis plant. These tiny mushroom-like structures cover the flowers and leaves of the cannabis plant.
The chemical formula of THCV is C19H26O2. Although it is present in small amounts in cannabis flowers, selective breeding has resulted in chemovars with slightly higher concentrations. Nevertheless, THCV is generally not the predominant cannabinoid in cannabis strains.
Origin and synthesis of THCV
THCV is derived from CBGVA or cannabigerovanic acid, along with CBGA (cannabigerolic acid), the two basic cannabinoid precursors in the cannabis plant. While laboratory synthesis is possible, it is not commonly practiced.
The process by which the cannabis plant produces its cannabinoid compounds is called cannabinoid biosynthesis. CBGVA is converted into THCVA by the enzyme THCA synthase. Under the influence of heat and light, THCVA is then decarboxylated to THCV. Synthesis in the laboratory is not yet common for commercial purposes.
Differences between THCV, THC and CBD
In contrast to the well-known THC, THCV is characterized by low psychoactive activity, which offers potential therapeutic benefits without causing strong psychotropic effects.
The chemical structure of THCV differs from both THC and CBD, which affects its interactions with receptors in the endocannabinoid system.
Properties and effects of THCV
Some properties of THCV are similar to those of CBD, such as possible anti-inflammatory effects and benefits in neurological disorders. On the other hand, studies suggest that THCV, unlike other cannabinoids, may be useful in weight control, diabetes and obesity through glucose metabolism.
THCV and the endocannabinoid system
THCV interacts with the human body's endocannabinoid system via CB1 and CB2 receptors. Similar to THC and CBD, THCV can bind to CB1 and CB2 receptors.
THCV exhibits a special interaction with these receptors. When it binds to the CB1 receptor, it does so through "inverse agonism," meaning it reduces the receptor's activity. This is in contrast to the psychoactive response normally associated with CB1 receptor activation. Although THCV may attenuate the psychoactive effects of THC, the exact mechanisms are not yet known.
Potential benefits and therapeutic applications of THCV
The potential effects of THCV range from anti-inflammatory properties to anti-epileptic effects to helping regulate glucose and reducing hunger. These therapeutic possibilities are suggested by preclinical or experimental studies, and further research may provide new insights.
How do you take THCV?
THCV can be found in cannabis flowers and its byproducts such as oils, tinctures and concentrates, provided they are full spectrum. Some countries also offer edible products such as gummies that contain THCV isolated from the cannabis plant.
The THCV dose studied in humans so far is 5 mg twice daily. The clinical study using this dose was conducted on patients with type 2 diabetes.
THCV side effects and toxicity
THCV appears to have a relatively favorable safety profile. No serious adverse effects or side effects have been reported to date. Since further research is needed, the toxicity of THCV cannot be ruled out.
Will THCV test positive on a drug test?
THCV may test positive on a specific screening test, but not on standard urine doping tests for THC. THCV is structurally different from THC and is therefore likely to be undetectable on a standard drug test.
Legal status and regulation of THCV
As a non-psychoactive cannabinoid found in small amounts in cannabis, THCV is not currently illegal. However, it is not approved for use in food in European countries, so it is not currently found in supplements or foods.
THCV is emerging as a promising cannabinoid with unique properties. The benefits of THCV may open up further research opportunities in the future and impact people's health and well-being. This article is for informational purposes only and is not a substitute for professional medical advice. Before using any CBD products, it is recommended to consult a doctor.
Update June 26, 2024: As part of the fifth regulation amending the appendix to the New Psychoactive Substances Act, some cannabinoids have been banned in Germany. These include THC-PO, THC-P, THCV, HHC and all associated derivatives (HHC-O, HHC-P, HHC-PO...). The bans are limited to the production and sale of the cannabinoids. The consumption and possession of the cannabinoids is still legal. We are just not allowed to sell them to you.
As a replacement, FlowPow offers 10-OH-HHC and 10-OH-HHCP Products are available for sale that have the same psychoactive effect and are currently not regulated in Germany.
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